NMR Course at Einstein

Course 7011: NMR for Chemistry and Biochemistry

Einstein Academic Calendar: https://einsteinmed.edu/education/phd/current-students/calendar.aspx 

Course offered in 2023/2024: 

Block II 13 weeks: November 27, 2023 – March 4, 2024

Start Date: Monday, November 27, 2023

Days/Times/Location: Mondays & Wednesdays, 10:40am - 11:50am in Ullmann B-8 (unless otherwise specified on syllabus)


COURSE DESCRIPTION: The course will provide a gentle but thorough introduction to basic NMR theory and principles followed by application of NMR to solving various chemical and biochemical problems. Topics will include one-, two-, and 3-dimensional NMR methods applied to: the covalent structure and conformation of small molecules and macromolecules, ligand binding and exchange rates, pKa values, and enzyme mechanisms. Lectures will be combined with hands-on sessions in the NMR lab, where students will be assigned projects to be completed on the NMR spectrometers. 

NOTE: there are approximately 8 labs that will require some time outside of the assigned block to complete - prepare to spend 1-2 hours for each lab (about one per week) to run experiments and/or analyze data on your own time.

COURSE OBJECTIVES: Students will acquire the basic skills for running NMR experiments and interpreting NMR data from a variety of applications in chemistry and structural biology.

REQUIRED MATERIALS: Computer or laptop.

PREREQUISITES/BACKGROUND PREPARATION: A general familiarity with organic chemistry and biochemistry.

SUITABLE FOR 1ST YEAR STUDENTS: Yes

STUDENT ASSESSMENTS:

Lab reports and problem sets: 75%

Scores on late reports/problem sets are discounted 10%/day; lowest score will be dropped

Presentation: 25%

Score based on

- Introduction to paper and problem studied

- NMR methods and details of experiments performed

- Summary and discussion of results

- Conclusions, future directions and timing of talk

Grade required to pass: 65/100; w/ Honors: 93



SYLLABUS FOR 2023/2024: NMR Course Syllabus

COURSE MATERIAL AND READINGS: NMR Course Material and Readings